March 10, 2010 – 11:07 pm
- “Resveratrol is a potent inhibitor of inflammation and has anti-diabetic potentiality, however whether its anti-inflammatory potency contributes to the amelioration of diabetes or insulin resistance remains to be determined.”1
- “… effects of resveratrol on inflammation-related adipokines expression and insulin sensitivity in adipocytes.”
Researchers from Department of Pharmacology for Chinese Material Medica, China Pharmaceutical University, Nanjing, Jiangsu, China; have presented an article titled: “Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses.”
The researchers from Nanjing, Jiangsu, China; have also noted:
- “We stimulated RAW264.7 cells with LPS and collected the supernatant as a conditioned medium (CM) for the culture of adipocytes.”
- “Resveratrol, at concentrations ranging from 0.1 to 10 muM, effectively inhibited lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 production with the downregulation of relative genes expression in macrophages.”
- “Exposing differentiated 3T3-L1 cells to RAW264.7 CM resulted in gene over-expressions of TNF-alpha, IL-6 and resistin, however, mRNA expression of adiponectin and PPARgamma were down-regulated.”
- “Pretreatment of CM from resveratrol-treated macrophages reduced the elevated levels of TNF-alpha and IL-6, and significantly reversed inflammation-related changes in adipokine gene expression in 3T3-L1 adipocytes.”
- “Resveratrol suppressed extracellular receptor-activated kinase (ERK) and transcription factor-kappaB (NF-kappaB) activation by reducing the phosphorylation of ERK1/2 and NF-kappaB p65; moreover, it modulated insulin signaling transduction by modification of Ser/Thr phosphorylation of insulin receptor substrate-1 (IRS-1) and downstream AKT (T308), and thereby improved insulin sensitivity in adiposities.”
- “These results demonstrated that resveratrol modulated adipokines expression and improved insulin sensitivity which relative to inhibition of inflammatory-like response in adipocytes.”
(1) Kang L, Heng W, Yuan A, Baolin L, Fang H: Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses. Biochimie. 2010 Feb 25; (Article in Press)
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Tagged activation, adiponectin, ameliorate, anti-inflammatory, China, china pharmaceutical, concentration, contribute, diabetes, down-regulates, downregulation, expression, gene expression, inflammation, inflammatory responses, insulin, insulin receptor substrate, insulin resistance, insulin sensitivity, jiangsu china, levels, lipopolysaccharide, lipopolysaccharides, macrophages, modulation, nanjing, pharmaceutical, pharmaceutical university, phosphorylation, potent inhibitor, potentially, production, receptors, reduce, reduced, resistin, resveratrol, reverse, transcription factor
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- “In vitro and animal studies show that polyphenols from olives have potent antioxidant activities; 50 % of the phenolic compounds contained in olives and virgin olive oil are hydroxytyrosol and derivatives thereof.”1
Researchers from DSM Nutritional Products Ltd, Department of Human Nutrition and Health, Basel, Switzerland; have presented an article titled: “Antioxidant activity of olive polyphenols in humans: a review.”
The researchers from DSM Nutritional Products Ltd, Department of Human Nutrition and Health, Basel, Switzerland; have also noted
- “Hydroxytyrosol is the major olive polyphenol consumed and well absorbed in humans.”
- “It is considered to have the highest antioxidant potency compared to the other olive polyphenols.”
- “Review of the human intervention studies showed that olive polyphenols decreased the levels of oxidized-LDL in plasma and positively affected several biomarkers of oxidative damage.”
- “The antioxidant effects of olive polyphenols on low-density lipoprotein (LDL) oxidation are observed after a dietary intake of about 10 mg per day.”
- “The overall evidence from in vitro assays, and animal and human studies support the antioxidant effect of olive polyphenols.”
- “However, further larger human studies are needed to clarify the effect of olive polyphenols on markers of oxidative stress, particularly DNA damage and plasma isoprostane levels.”
(1) Raederstorff D: Antioxidant activity of olive polyphenols in humans: a review. Int J Vitam Nutr Res. 2009 May;79(3):152-65.
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Tagged activation, antioxidant activities, antioxidant effect, antioxidant effects, antioxidants, assays, basel switzerland, biomarker, biomarkers, decreases, dietary, dietary intake, dna damage, dsm nutritional products, health, human, human intervention, human nutrition, intake, intervention studies, isoprostane, isoprostanes, levels, low density lipoprotein, markers, nutrition, nutrition and health, oil studies, phenolic compounds, polyphenol, polyphenols, production, stress, support, virgin olive oil
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Boston University School of Medicine scientists have reported:
- ‘… a new syndrome affecting potentially thousands of hospital inpatients.’
- ‘Coined SHAKE (Supplement-associated Hyperammonemia After C(K)achetic Episode), the condition, which results in altered mental status and difficulty walking, can be prevented by excluding high protein dietary supplements in a patients’ diet if they have experienced poor eating for more than a week prior to their admittance.’
Michael Perloff MD PhD, from the Department of Neurology at Boston University School of Medicine, has said:
- “When an altered mental status occurs in the inpatient setting, many possible causes are considered. However, in these two medically complex patients, the initiation of high-protein dietary supplements was probably discounted, if even noticed …”
- “With advances in nutritional education and supplements, this syndrome likely occurs thousands of times per year in hospitals across the United States.”
- “We believe it may account for more than 10,000 hospital days, countless morbidity and even some mortality …”
More from a Release dated March 8, sourced from Boston University Medical Center:
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Tagged activation, admittance, altered mental status, archives of internal medicine, blood, boston researchers, boston university medical, boston university medical center, boston university school, boston university school of medicine, busm, center, cognition, consciousness level, department of neurology, diet, dietary, dietary supplements, difficulty walking, disease, experiments, function, herring, hospitalization, initiates, intake, levels, liver, michael perloff, morbidity, neurology, normalization, nutrition, nutritional education, potentially, prevention, protein, reduced, school of medicine, slow, stops, symptoms, university medical center
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- “Zinc has earned recognition recently as a micronutrient of outstanding and diverse biological, clinical, and global public health importance.”1
- “Regulation of absorption by zinc transporters in the enterocyte, together with saturation kinetics of the absorption process into and across the enterocyte, are the principal means by which whole-body zinc homeostasis is maintained.”
- “Several physiologic factors, most notably the quantity of zinc ingested, determine the quantity of zinc absorbed and the efficiency of absorption.”
- “Other factors are age and the time over which zinc is ingested.”
Researchers from the Department of Pediatrics Section of Nutrition University of Colorado Denver, in Denver, Colorado, USA; and from Shanghai Jiao Tong University School of Medicine Xin-Hua Hospital, Shanghai, China; have presented an article titled: “Zinc bioavailability and homeostasis.”
The researchers from Denver and Shanghai have also noted:
- “Zinc from supplements has not been shown to be absorbed differently from that taken with meals that lack inhibitors of zinc absorption.”
- “The principal dietary factor known to impair zinc bioavailability is inositol hexa- (and penta-) phosphate or phytate.”
- “Modeling of zinc absorption as a function of dietary zinc and phytate accounts for >80% of the variability in the quantity of zinc absorbed.”
- “Fitting the model to new data has resulted in continual improvement in parameter estimates, which currently indicate a maximal absorption in adults of approximately 6 mg Zn/d and that the average estimated dietary requirement doubles with 1000 mg dietary phytate/d.”
- “Intestinal excretion of endogenous zinc is regulated in response to recent absorption and to zinc status.”
- “The quantitative relation of intestinal excretion of endogenous zinc to zinc absorption is currently considered to be of major importance in the determination of zinc requirements.”
- “The effects of phytate on intestinal losses of endogenous zinc merit further investigation but are probably not of the same magnitude as its inhibitory effects on absorption of exogenous zinc.”
(1) Hambidge KM, Miller LV, Westcott JE, Sheng X, Krebs NF: Zinc bioavailability and homeostasis. Am J Clin Nutr. 2010 Mar 3; (Article in Press)
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Tagged aging, bioavailability, China, continual improvement, denver colorado usa, dietary, dietary factor, dietary requirement, dietary zinc, function, global public health, health, homeostasis, hospitalization, ingestion, intestines, jiao tong university, maintain, micronutrient, model, nutrition, parameter estimates, pediatric, public health importance, Shanghai, shanghai china, shanghai jiao tong university, university of colorado denver, variability, zinc, zinc absorption, zinc status
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Professor Carsten Geisler from University of Copenhagen’s Department of International Health, Immunology and Microbiology has indicated that “… when a T cell is exposed to a foreign pathogen, it extends a signaling device or ‘antenna’ known as a vitamin D receptor, with which it searches for vitamin D. This means that the T cell must have vitamin D or activation of the cell will cease. If the T cells cannot find enough vitamin D in the blood, they won’t even begin to mobilize.”
More from a Release dated March 7, sourced from University of Copenhagen:
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Koushik Adhikari, Assistant Professor of Sensory Analysis, from Kansas State University, has said:
- “Nutrigenomics involves tailoring diets to someone’s genetic makeup …”
- “I speculate that in five to 10 years, you would go to a genetic counselor or a physician who could help you understand your genetic makeup, and then a nutritional professional could customize your diet accordingly.”
More from a Release dated March 5, sourced from Kansas State University:
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Tagged bitter, cancer, cholesterol, chronic, complete, diabetes, diet, disease, disease prevention, expression, fat, food technology, foods, fruit, future of public health, gene expression, genetic counselor, genetic makeup, health, health recommendations, herring, human, human nutrition, incidence, industries, issue, kansas state university, levels, michigan, michigan state university, nutrients, nutrigenomics, nutrition, obesity, potentially, prevention, risk, school of osteopathic medicine, scientists, sensory analysis, state researchers, taste
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Professor Sue Penckofer PhD RN, from University Chicago Marcella Niehoff School of Nursing, has said:
- “Vitamin D deficiency continues to be a problem despite the nutrient’s widely reported health benefits …”
- “Chicago winters compound this issue when more people spend time away from sunlight, which is a natural source of vitamin D.”
More from a Release dated March 3, sourced from Loyola University Health System:
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Tagged additives, adequate, aging, blood, blood sugar control, chicago winters, chicagoans, chronic, cold, cold weather, costs, decreases, diabetes, diabetes patients, diet, dietary, dietary intake, disease, health, health benefits, insulin, insulin resistance, intake, issue, levels, long winter, loyola faculty members, loyola university chicago, loyola university health, natural source, nutrients, reduced, risk, school of nursing, source of vitamin d, sugar, symptoms, treatment, university health system, vitamin d, vitamin d deficiency, vitamin d2, vitamin d3, vitamins
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- “Pine bark extract (PBE) mainly contains proanthocyanidin in oligomers.”1
- “It has many physiological effects, including antioxidant, anti-inflammatory, and so on.”
Researchers from Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan; have presented an article titled: “Dietary pine bark extract reduces atherosclerotic lesion development in male ApoE-deficient mice by lowering the serum cholesterol level.”
The researchers from Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan. masaos@agr.kyushu-u.ac.j; have also noted:
- “… investigated whether PBE has an anti-atherogenic effect on apoE-deficient mice.”
- “Male and female mice were fed a diet based on an AIN-76 formula (control diet), and that diet supplemented with 2% PBE (the PBF diet).”
- “The PBE diet, compared with the control diet, resulted in lowering the body weight gain and the adipose tissue weight in both male and female mice.”
- “The lesion area of the valve and the levels of serum and liver cholesterol in the male mice decreased on the PBE diet.”
- “The PBE diet had no significant effect on the levels of urinary isoprostanes or serum thiobarbituric acid reactive substances.”
- “These results indicate that dietary PBE can have beneficial effects on atherosclerosis development in male apoE-deficient mice by lowering the serum cholesterol level.”
(1) Sato M, Yamada Y, Matsuoka H, Nakashima S, Kamiya T, Ikeguchi M, Imaizumi K: Dietary pine bark extract reduces atherosclerotic lesion development in male ApoE-deficient mice by lowering the serum cholesterol level. Biosci Biotechnol Biochem. 2009 Jun;73(6):1314-7. Epub 2009 Jun 7.
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Tagged adipose tissue weight, anti-inflammatory, antioxidants, atherosclerosi, atherosclerosis, bioenvironmental, bioresource, body weight gain, chemistry division, cholesterol, control diet, decreases, deficient mice, developed, diet, dietary, extract, female mice, fukuoka japan, isoprostanes, japan, kyushu university, lesion development, levels, liver, liver cholesterol, male mice, nutrition, nutrition chemistry, oligomers, pine bark extract, proanthocyanidins, reactive substances, reduce, serum cholesterol, serum cholesterol level, serum thiobarbituric acid reactive substances, tissues, urinary isoprostanes
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Arthur Klatsky MD, Senior consultant in Cardiology from Kaiser Permanente Division of Research in Oakland, California, has said:
- “Coffee drinking is related to lower risk of hospitalization for rhythm problems, but the association does not prove cause and effect, or that coffee has a protective effect …”
- “However, these data might be reassuring to people who drink moderate amounts of coffee that their habit is not likely to cause a major rhythm disturbance,”
More from a Release dated March 2, sourced from Kaiser Permanente:
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Tagged activation, active ingredient in coffee, american heart association, atrial fibrillation, caffeine, caffeine intake, cardiology, cardiovascular disease epidemiology, chronic, coffee drinkers, consumption, dietary, disease, drink, epidemiology, examination, health, heart rhythm disturbances, hospitalization, intake, kaiser permanente study, men and women, oakland calif, population study, prevention, protects, quality, reduce, research presentation, risk, study in denmark, support, surprise, symptoms
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